Linked Life Data

19627763

Source:http://linkedlifedata.com/resource/pubmed/id/19627763

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2009-7-24
pubmed:abstractText
Gastroenteropancreatic neuroendocrine tumours (GEP NETs) originate from the neuroendocrine cells through the gastrointestinal tract and endocrine pancreas. The embryologic development of the pancreas is a complex process that begins with the "stem cell" that come from the endodermus. These cells go through two phases: in the first transition the "stem cell" differentiates in exocrine and endocrine cells. This process is regulated by transcription factors such as Pdx1 ("insulin promoter factor 1"), Hlxb6 and SOX9. In the second transition the neuroendocrine cell differentiates in the 5 cell types (alpha, beta, delta, PP y epsilon.). This process is regulated through the balance between factors favoring differentiation (mainly neurogenin 3) and inhibitor factors which depend on Notch signals. The existence of a third transition in postnatal pancreas is hypothesized. The "stem cell" from pancreatic ducts would become adult beta cells, through autoduplication and neogenesis. In the small gut of the adult the stem cell are placed in the intestinal crypts and develop to villi in secretor lines (enterocytes, globet and Paneths cells) or neuroendocrine cells from which at least 10 cell types depend. This process is regulated by transcription factors: Math1, neurogenina 3 and NeuroD.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
1579-2021
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
56 Suppl 2
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
[Neuroendocrine system of the pancreas and gastrointestinal tract: origin and development].
pubmed:affiliation
Endocrinología y Nutrición, Hospital Clínico San Carlos, Madrid, España. joseangeldiaz@mixmail.com
pubmed:publicationType
Journal Article, English Abstract