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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2010-1-12
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pubmed:abstractText |
BACKGROUND AND PURPOSE Corticosteroid treatment is associated with osteonecrosis of the femoral head (ON) in certain patients. The degree of drug sensitivity in general is governed by genetic variation between individuals. We investigated the relationship between ON and the presence of different alleles of the cytochrome P450 gene (CYP3A4), the product of which metabolizes corticosteroids, and of the P-glycoprotein (P-gp) gene (ABCBI), the product of which modulates cellular uptake of corticosteroids, to determine whether patients with certain alleles may be at higher risk of ON after corticosteroid treatment.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-10716719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-11181494,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-11356939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-11375290,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-11503014,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-11697464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-12089380,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-12228187,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-12355139,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-12419946,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-12426521,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-12690862,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-12768474,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-12817518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-14578760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-14583680,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-15684873,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-1574093,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-15934077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-16847760,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-16981844,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-17787012,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-17940133,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-3493777,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-7681059,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-8065806,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-9155153,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19626470-9789061
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
1745-3674
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
325-9
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19626470-Adolescent,
pubmed-meshheading:19626470-Adrenal Cortex Hormones,
pubmed-meshheading:19626470-Adult,
pubmed-meshheading:19626470-Child,
pubmed-meshheading:19626470-Cohort Studies,
pubmed-meshheading:19626470-Cytochrome P-450 CYP3A,
pubmed-meshheading:19626470-Femur Head Necrosis,
pubmed-meshheading:19626470-Genotype,
pubmed-meshheading:19626470-Humans,
pubmed-meshheading:19626470-Lipid Metabolism,
pubmed-meshheading:19626470-Middle Aged,
pubmed-meshheading:19626470-P-Glycoprotein,
pubmed-meshheading:19626470-Pharmacogenetics,
pubmed-meshheading:19626470-Polymorphism, Genetic,
pubmed-meshheading:19626470-Polymorphism, Single Nucleotide,
pubmed-meshheading:19626470-Risk Factors,
pubmed-meshheading:19626470-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Incidence of genetic polymorphisms involved in lipid metabolism among Chinese patients with osteonecrosis of the femoral head.
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pubmed:affiliation |
Department of Orthopaedics, First Affiliated Hospital of Guangzhou, University of Traditional Chinese Medicine, BaiYun District, Guangzhou, China.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't,
Multicenter Study
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