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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
12
|
pubmed:dateCreated |
1992-1-7
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pubmed:abstractText |
Studies were undertaken to evaluate the role of interleukin 6 (IL-6) in the pathogenesis of chronic hepatitis B. Using recently developed sensitive and specific enzyme-linked immunosorbent assay, we determined serum levels of IL-6 in patients with chronic active hepatitis B (B-CAH), chronic persistent hepatitis B (B-CPH), and primary biliary cirrhosis (PBC). Serum IL-6 activity tended to increase in patients with B-CAH (38.4 +/- 68.0 pg/ml) (+/- SD), compared with controls (9.7 +/- 6.8 pg/ml), although the difference was not significant because of the wide scatter in values. IL-6 levels in B-CPH and PBC were similar to those of controls. There was a significant correlation between the levels of IL-6 and aminotransferase in B-CAH. In addition, IL-6 activity was significantly enhanced during acute exacerbation of the illness, accompanied by clearance of HBeAg. Patients who received IFN-alpha and IL-2 therapy showed depressed IL-6 activity during treatment, and a rebound beyond pretreatment values after cessation of therapy. These findings suggest that IL-6 plays a role in the development of chronic hepatitis B, and it may contribute, at least in part, to the elimination of HB virus.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0002-9270
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
86
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1804-8
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1962626-Adult,
pubmed-meshheading:1962626-Chronic Disease,
pubmed-meshheading:1962626-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1962626-Female,
pubmed-meshheading:1962626-Hepatitis, Chronic,
pubmed-meshheading:1962626-Hepatitis B,
pubmed-meshheading:1962626-Humans,
pubmed-meshheading:1962626-Interleukin-6,
pubmed-meshheading:1962626-Liver Cirrhosis, Biliary,
pubmed-meshheading:1962626-Male,
pubmed-meshheading:1962626-Middle Aged,
pubmed-meshheading:1962626-Transaminases
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pubmed:year |
1991
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pubmed:articleTitle |
Serum interleukin 6 levels in patients with chronic hepatitis B.
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pubmed:affiliation |
Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.
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pubmed:publicationType |
Journal Article
|