|
pubmed:abstractText |
Potent 3,4-disubstituted benzofuran P1' MMP-13 inhibitors have been prepared. Selectivity over MMP-2 was achieved through a substituent at the C4 position of the benzofuran P1' moiety of the molecule. By replacing a backbone benzene with a pyridine and valine with threonine, compounds (e.g., 44) with greatly reduced plasma protein binding were also obtained.
|
|
pubmed:affiliation |
Department of Chemical Sciences, Wyeth Research, 200 CambridgePark Drive, Cambridge, MA 02140, USA.
|
