Source:http://linkedlifedata.com/resource/pubmed/id/19624485
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
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| pubmed:dateCreated |
2009-9-24
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| pubmed:abstractText |
Human leukocyte antigen-G (HLA-G) expression is a potential factor for the pathogenesis of virus infection. A 14 bp insertion/deletion polymorphism (rs16375) in the 3'-untranslated region of the HLA-G gene is involved in the stability of HLA-G mRNA and HLA-G protein expression. Therefore, the HLA-G 14 bp polymorphism might be involved in human cytomegalovirus (hCMV) infection. To test a possible association between the HLA-G 14 bp deletion/insertion polymorphism and the active hCMV infection, in this study, a total of 54 patients with active hCMV infection and 165 age- and sex-matched, unrelated, normal Chinese Han population were genotyped for the 14 bp insertion/deletion polymorphism. Association of 14 bp polymorphism with hCMV urine DNA copies and the odds ratio (OR) of the polymorphism as a risk factor for active hCMV infection were analyzed. Our results showed that the prevalence of -14 bp/ -14 bp genotype in active hCMV patients was markedly increased [P(c) = 0.00034, OR = 3.31, 95% confidence interval (CI): 1.77-6.18], and similar significance was also observed for the frequency of -14 bp allele (P c = 0.0023, OR = 2.24, 95% CI: 1.38-3.64) when compared with that of healthy controls. Furthermore, urine hCMV DNA copies in patients with the -14 bp/ -14 bp genotype were significantly higher than those in patients with the +14 bp/ +14 bp genotype (P = 0.041). Our findings support a potential role of HLA-G 14 bp insertion/deletion polymorphism as a susceptible factor for the active hCMV infection.
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| pubmed:commentsCorrections | |
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/HLA Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-G Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class I,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin M
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| pubmed:status |
MEDLINE
|
| pubmed:month |
Oct
|
| pubmed:issn |
1399-0039
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
74
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| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
317-21
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| pubmed:dateRevised |
2011-11-17
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| pubmed:meshHeading |
pubmed-meshheading:19624485-Case-Control Studies,
pubmed-meshheading:19624485-Child, Preschool,
pubmed-meshheading:19624485-Cytomegalovirus,
pubmed-meshheading:19624485-Cytomegalovirus Infections,
pubmed-meshheading:19624485-DNA, Viral,
pubmed-meshheading:19624485-Disease Susceptibility,
pubmed-meshheading:19624485-Female,
pubmed-meshheading:19624485-Gastrointestinal Diseases,
pubmed-meshheading:19624485-HLA Antigens,
pubmed-meshheading:19624485-HLA-G Antigens,
pubmed-meshheading:19624485-Hepatitis,
pubmed-meshheading:19624485-Histocompatibility Antigens Class I,
pubmed-meshheading:19624485-Humans,
pubmed-meshheading:19624485-Immunoglobulin G,
pubmed-meshheading:19624485-Immunoglobulin M,
pubmed-meshheading:19624485-Infant,
pubmed-meshheading:19624485-Male,
pubmed-meshheading:19624485-Mutagenesis, Insertional,
pubmed-meshheading:19624485-Pneumonia,
pubmed-meshheading:19624485-Polymerase Chain Reaction,
pubmed-meshheading:19624485-Polymorphism, Genetic,
pubmed-meshheading:19624485-Purpura, Thrombocytopenic, Idiopathic,
pubmed-meshheading:19624485-Sequence Deletion
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| pubmed:year |
2009
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| pubmed:articleTitle |
The HLA-G 14 bp insertion/deletion polymorphism is a putative susceptible factor for active human cytomegalovirus infection in children.
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| pubmed:affiliation |
Department of Laboratory Medicine, The Second Hospital, Wenzhou Medical College, Zhejiang, China.
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| pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|