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pubmed-article:19622350pubmed:abstractTextChronic inflammation of the airways and lung parenchyma plays a major role in the pathogenesis of chronic obstructive pulmonary disease (COPD). It is influenced by both environmental and genetic factors. CD40 signaling has been linked to pathogenic processes of chronic inflammatory diseases. After interaction with its ligand CD154 (CD40L), CD40 induces a broad variety of chronic inflammatory responses, inducing the release of inflammatory mediators. We investigated whether a CD40 gene (-1C/T) single nucleotide polymorphism (SNP) is associated with COPD in a Chinese population.lld:pubmed
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pubmed-article:19622350pubmed:articleTitleAssociation of CD40 -1C/T polymorphism in the 5'-untranslated region and chronic obstructive pulmonary disease.lld:pubmed
pubmed-article:19622350pubmed:affiliationDepartment of Forensic Biology, West China School of Preclinical and Forensic Medicine, Sichuan University, PR China.lld:pubmed
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