Linked Life Data

19621399

Source:http://linkedlifedata.com/resource/pubmed/id/19621399

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
34
pubmed:dateCreated
2009-8-26
pubmed:abstractText
We have identified the first highly efficient intramolecular general base catalysis (IGBC) of a hydrolysis reaction, in a system where two general bases are available to assist the attack of the same nucleophilic water molecule. The suggested mechanism, available uniquely to a phosphate triester model, is readily available in enzyme active sites, and the results suggest a possible solution to the long-unsolved question of how enzymes are able to activate a water molecule to be a highly effective nucleophile.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1521-3765
pubmed:author
pubmed:issnType
Electronic
pubmed:day
24
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
8475-9
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Activating water: efficient intramolecular general base catalysis of the hydrolysis of a phosphate triester.
pubmed:affiliation
University Chemical Laboratory, Cambridge CB2 1EW, UK. ajk1@cam.ac.uk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't