Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-8-4
pubmed:abstractText
The cytotoxic activity of lymphocytes is crucial for immune surveillance and homeostasis. Several independent, naturally occurring genetic models characterized by defects in granule trafficking or exocytosis have helped to decipher the multiple steps and molecules that regulate the cytotoxic process. The study by Rüder and colleagues in this issue of the JCI shows that an engineered absence of EBAG9, previously reported as a tumor-associated antigen, enhances cytotoxic activity of CTLs but not NK cells, likely acting on the endosomal-lysosomal trafficking of the cytotoxic effectors (see the related article beginning on page 2184). This finding adds a new piece to the puzzle of complex mechanisms that tightly regulate the capacity of the cytotoxic response and suggests a new target to negatively modulate CTL responsiveness.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-10024875, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-10835631, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-11082062, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-11208072, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-11984006, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-14566336, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-14622600, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-15069016, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-15582491, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-15635093, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-15661029, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-15702992, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-16837549, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-17124515, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-17182842, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-17237785, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-17433652, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-17450176, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-17506701, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-17628466, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-18772139, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-18941173, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-18991284, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-19620783, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-8717042, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-8896560, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620775-9606205
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1558-8238
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
119
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2136-40
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
EBAG9 tempers lymphocyte killing activity.
pubmed:affiliation
INSERM U768, Paris, France.
pubmed:publicationType
Journal Article, Comment, Research Support, Non-U.S. Gov't