Linked Life Data

19620337

Source:http://linkedlifedata.com/resource/pubmed/id/19620337

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
2009-9-22
pubmed:abstractText
Nevirapine is a nonnucleoside reverse transcriptase inhibitor used as part of combination therapy for human immunodeficiency virus (HIV) infection. Nevirapine may be prescribed for patients with hepatic fibrosis and cirrhosis. Significant autoinduction of cytochrome P450 3A4 and 2B6 following multiple dosing prompted an assessment of the metabolic profiles in patients with liver disease receiving chronic nevirapine therapy. HIV-infected patients with hepatic fibrosis who were receiving a stable antiretroviral regimen containing nevirapine for > or = 6 weeks had liver biopsy specimens assessed by Ishak histologic scoring and were grouped by severity (group 1, Ishak scores of 1 and 2; group 2, Ishak scores of 3 and 4; group 3, Ishak scores of 5 and 6). Steady-state trough nevirapine levels were determined for all patients, and additional measurements were obtained at 1, 2, and 4 h following nevirapine dosing for a subset of patients. The pharmacokinetics of nevirapine and its five metabolites were characterized, and a comparison of the results for the different Ishak groups was performed. Among 51 patients with hepatic fibrosis, the majority of whom were coinfected with hepatitis C virus or hepatitis B virus, differences between the maximum and the minimum observed plasma concentrations demonstrated a statistically significant flattening of the systemic exposure curves with progression from Ishak group 1 to Ishak group 2 or 3, suggesting a decrease in systemic clearance with the progression of liver disease. However, there were no significant differences in the trough and the maximum nevirapine concentrations between the Ishak groups. The metabolite profiles were also comparable across the Ishak groups. In HIV-infected patients who were chronically treated with nevirapine and who had various degrees of hepatic fibrosis, including cirrhosis, trough plasma nevirapine concentrations were not significantly increased, and thus, no dose adjustment is warranted.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-10421616, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-10631618, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-10701699, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-10704012, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-15075511, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-15078193, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-15751772, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-16038474, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-17330787, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-18171229, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-7560864, http://linkedlifedata.com/resource/pubmed/commentcorrection/19620337-8602375
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1098-6596
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
53
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
4147-52
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Pharmacokinetic assessment of nevirapine and metabolites in human immunodeficiency virus type 1-infected patients with hepatic fibrosis.
pubmed:affiliation
Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CT 06877, USA. annamaria.cammett@boehringer-ingelheim.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Clinical Trial, Phase IV