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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-11-17
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pubmed:abstractText |
Cardiac L-type Ca(2+)-currents show distinct alterations in chronic heart failure, including increased single-channel activity and blunted adrenergic stimulation, but minor changes of whole-cell currents. Expression of L-type Ca(2+)-channel beta(2)-subunits is enhanced in human failing hearts. In order to determine whether prolonged alteration of Ca(2+)-channel gating by beta(2)-subunits contributes to heart failure pathogenesis, we generated and characterized transgenic mice with cardiac overexpression of a beta(2a)-subunit or the pore Ca(v)1.2 or both, respectively.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1755-3245
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
1
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pubmed:volume |
84
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
396-406
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pubmed:dateRevised |
2011-3-3
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pubmed:meshHeading |
pubmed-meshheading:19620129-8-Bromo Cyclic Adenosine Monophosphate,
pubmed-meshheading:19620129-Animals,
pubmed-meshheading:19620129-Arrhythmias, Cardiac,
pubmed-meshheading:19620129-Calcium Channels, L-Type,
pubmed-meshheading:19620129-Chronic Disease,
pubmed-meshheading:19620129-Disease Models, Animal,
pubmed-meshheading:19620129-Fibrosis,
pubmed-meshheading:19620129-Heart Failure,
pubmed-meshheading:19620129-Heart Rate,
pubmed-meshheading:19620129-Humans,
pubmed-meshheading:19620129-Mice,
pubmed-meshheading:19620129-Mice, Transgenic,
pubmed-meshheading:19620129-Myocardial Contraction,
pubmed-meshheading:19620129-Myocardium,
pubmed-meshheading:19620129-Myocytes, Cardiac,
pubmed-meshheading:19620129-Okadaic Acid,
pubmed-meshheading:19620129-Patch-Clamp Techniques,
pubmed-meshheading:19620129-Protein Subunits
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pubmed:year |
2009
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pubmed:articleTitle |
Transgenic simulation of human heart failure-like L-type Ca2+-channels: implications for fibrosis and heart rate in mice.
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pubmed:affiliation |
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Freiburg, Freiburg, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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