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pubmed-article:19620006pubmed:abstractTextA series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25microg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results.lld:pubmed
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pubmed-article:19620006pubmed:articleTitleDevelopment of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies.lld:pubmed
pubmed-article:19620006pubmed:affiliationEuropean Research Centre for Drug Discovery & Development, Università di Siena, Italy.lld:pubmed
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