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rdf:type |
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|
lifeskim:mentions |
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pubmed:issue |
16
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pubmed:dateCreated |
2009-8-11
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pubmed:abstractText |
A series of 4-quinolylhydrazones was synthesized and tested in vitro against Mycobacterium tuberculosis. At a concentration of 6.25microg/mL, most of the newly synthesized compounds displayed 100% inhibitory activity against M. tuberculosis in cellular assays. Further screening allowed the identification of very potent antitubercular agents. Compound 4c was also tested in a time-course experiment and against mtb clinical isolates, displaying interesting results.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1464-3391
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pubmed:author |
pubmed-author:AltarelliMariaM,
pubmed-author:ButiniStefaniaS,
pubmed-author:CamodecaCaterinaC,
pubmed-author:CampianiGiuseppeG,
pubmed-author:ChiasseriniLuisaL,
pubmed-author:ClarizioSandraS,
pubmed-author:CocconeSalvatore SannaSS,
pubmed-author:DeloguGiovanniG,
pubmed-author:GemmaSandraS,
pubmed-author:KumarVinodV,
pubmed-author:NovellinoEttoreE,
pubmed-author:SaviniLuisaL,
pubmed-author:TripaldiPierangelaP
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pubmed:issnType |
Electronic
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|
pubmed:day |
15
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
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pubmed:pagination |
6063-72
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pubmed:meshHeading |
|
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pubmed:year |
2009
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|
pubmed:articleTitle |
Development of antitubercular compounds based on a 4-quinolylhydrazone scaffold. Further structure-activity relationship studies.
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pubmed:affiliation |
European Research Centre for Drug Discovery & Development, Università di Siena, Italy.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
