Linked Life Data

19619678

Source:http://linkedlifedata.com/resource/pubmed/id/19619678

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-11-27
pubmed:abstractText
Porous scaffolds of a random co-polymer of omega-pentadecalactone (PDL) and epsilon-caprolactone (CL) (poly(PDL-CL)), synthesized by biocatalysis, were fabricated by supercritical carbon dioxide (scCO(2)) foaming. The co-polymer, containing 31 mol.% CL units, is highly crystalline (T(m) = 82 degrees C, DeltaH(m) = 105 J g(-1)) thanks to the ability of the two monomer units to co-crystallize. The co-polymer can be successfully foamed upon homogeneous absorption of scCO(2) at T > T(m). The effect of soaking time, depressurization rate and cooling rate on scaffold porosity, pore size distribution and pore interconnectivity was investigated by micro X-ray computed tomography. Scaffolds with a porosity in the range 42-76% and an average pore size of 100-375 microm were successfully obtained by adjusting the main foaming parameters. Process conditions in the range investigated did not affect the degree of crystallinity of poly(PDL-CL) scaffolds. A preliminary study of the mechanical properties of the scaffolds revealed that poly(PDL-CL) foams may find application in the regeneration of cartilage tissue.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1878-7568
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
6
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
130-6
pubmed:meshHeading
pubmed:year
2010
pubmed:articleTitle
Scaffold for tissue engineering fabricated by non-isothermal supercritical carbon dioxide foaming of a highly crystalline polyester.
pubmed:affiliation
Chemistry Department G. Ciamician and INSTM UdR Bologna, University of Bologna, Via Selmi 2, 40126 Bologna, Italy.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't