Linked Life Data

19619592

Source:http://linkedlifedata.com/resource/pubmed/id/19619592

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-10-19
pubmed:abstractText
The question whether lipid based - especially triglyceride based - depot systems can undergo biodegradation is despite many in vivo studies still unanswered. In this paper we studied biodegradation processes in vitro by incubating these lipid based systems in buffer media containing lipases. The main degradation product the free fatty acids (FFA) were isolated from the drawn samples and after derivatization analyzed with RP-HPLC. Lipid microparticles showed a rapid biodegradation whereas the complete degradation of compressed implants would take several months or years. For these two systems surface degradation can be stated. Surprisingly lipid based extrudates changed their structure dramatically upon lipase incubation resulting in a breakdown of the lipid matrix and formation of small lipid particles in the microm-range. This sort of bulk-degradation may enable the use of lipid based extrudates for the long term delivery of drugs. However additional in vivo experiments will be necessary to fully characterize these degradation processes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1873-4995
pubmed:author
pubmed:issnType
Electronic
pubmed:day
16
pubmed:volume
140
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
27-33
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Studies on the lipase induced degradation of lipid based drug delivery systems.
pubmed:affiliation
Ludwig-Maximilians-University Munich, Butenandtstr.5, 81377 Munich, Germany. martin.schwab@cup.uni-muenchen.de
pubmed:publicationType
Journal Article