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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-8-14
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pubmed:abstractText |
It has long been a matter of debate whether the hormone-sensitive lipase (HSL)-mediated lipolysis in pancreatic beta-cells can affect insulin secretion through the alteration of lipotoxicity. We generated mice lacking both leptin and HSL Lep(ob/ob)/HSL(-/-) and explored the role of HSL in pancreatic beta-cells in the setting of obesity. Lep(ob/ob)/HSL(-/-) developed elevated blood glucose levels and reduced plasma insulin levels compared with Lep(ob/ob)/HSL(+/+) in a fed state, while the deficiency of HSL did not affect glucose homeostasis in Lep(+/+) background. The deficiency of HSL exacerbated the accumulation of triglycerides in Lep(ob/ob) islets, leading to reduced glucose-stimulated insulin secretion. The deficiency of HSL also diminished the islet mass in Lep(ob/ob) mice due to decreased cell proliferation. In conclusion, HSL affects insulin secretary capacity especially in the setting of obesity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1090-2104
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pubmed:author |
pubmed-author:GotodaTakanariT,
pubmed-author:IgarashiMasakiM,
pubmed-author:IizukaYokoY,
pubmed-author:IshibashiShunS,
pubmed-author:IzumidaYoshihikoY,
pubmed-author:KadowakiTakashiT,
pubmed-author:KubotaMidoriM,
pubmed-author:KumagaiMasayoshiM,
pubmed-author:NagaiRyozoR,
pubmed-author:NishiMakikoM,
pubmed-author:OhashiKenK,
pubmed-author:OhtaKeisukeK,
pubmed-author:OkazakiHiroakiH,
pubmed-author:OsugaJun-ichiJ,
pubmed-author:SekiyaMotohiroM,
pubmed-author:ShimanoHitoshiH,
pubmed-author:TakanashiMikioM,
pubmed-author:TakaseSatoruS,
pubmed-author:TakeuchiYoshinoriY,
pubmed-author:TamuraYoshiakiY,
pubmed-author:YagyuHiroakiH,
pubmed-author:YahagiNaoyaN,
pubmed-author:YamadaNobuhiroN
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pubmed:issnType |
Electronic
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pubmed:day |
25
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pubmed:volume |
387
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
511-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19619509-Animals,
pubmed-meshheading:19619509-Blood Glucose,
pubmed-meshheading:19619509-Cell Proliferation,
pubmed-meshheading:19619509-Insulin,
pubmed-meshheading:19619509-Islets of Langerhans,
pubmed-meshheading:19619509-Mice,
pubmed-meshheading:19619509-Mice, Knockout,
pubmed-meshheading:19619509-Obesity,
pubmed-meshheading:19619509-Sterol Esterase,
pubmed-meshheading:19619509-Triglycerides
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pubmed:year |
2009
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pubmed:articleTitle |
Hormone-sensitive lipase deficiency suppresses insulin secretion from pancreatic islets of Lep ob/ob mice.
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pubmed:affiliation |
Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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