Linked Life Data

19618627

Source:http://linkedlifedata.com/resource/pubmed/id/19618627

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2009-7-21
pubmed:abstractText
Influenza infection is initiated by virus attachment to sialic acid-containing cell-surface receptors. The spectrum of sialylglycoconjugates varies substantially between viral host species as well as target tissues and cell types of the same species, leading to variations in the receptor-binding specificity of viruses circulating in these hosts. Therefore, receptor specificity plays an important role in the viral cell and tissue tropism, interspecies transmission and adaptation to a new host, and a poor fit of avian viruses to receptors in humans limits the emergence of new pandemic strains. Adaptation of an avian virus to a mammalian host also involves enhanced activity of the viral polymerase in mammalian cells which, in part, is the result of improved binding of the polymerase to the nuclear import machinery of the cell. These findings suggest that host range and virulence are the result of optimised molecular interactions between viral proteins and cellular factors. Future transmission studies with animals may reveal to what extent haemagglutinin receptor-binding mutations and polymerase-activity-enhancing mutations together enable influenza A viruses to cross species barriers.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0253-1933
pubmed:author
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-17
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Influenza receptors, polymerase and host range.
pubmed:affiliation
Institut für Virologie, Philipps-Universität Marburg, Hans-Meerwein-Str. 2, 35037 Marburg, Germany.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't