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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-7-20
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pubmed:abstractText |
Despite low incidence, ovarian cancer is the fifth leading cause of cancer deaths and it has the highest mortality rate of all gynecologic malignancies among US women. The mortality rate would be reduced with an early detection marker. The folate receptor alpha (FRalpha) is one logical choice for a biomarker because of its prevalent overexpression in ovarian cancer and its exclusive expression in only a few normal tissues. In prior work, it was observed that patients with ovarian cancer had elevated serum levels of a protein that bound to a FRalpha-specific monoclonal antibody relative to healthy individuals. However, it was not shown that the protein detected was intact functional FRalpha. In the current study, the goal was to determine whether ovarian cancer patients (n = 30) had elevated serum levels of a fully functional intact FRalpha compared to matched healthy controls (n = 30).
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-11174727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-12529343,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-1387884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-15590954,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-15745749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-15890779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-16172227,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-16482731,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-17062687,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-17473184,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-17487842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-17655275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-18222534,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-18287387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-2430957,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-3366900,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-3417674,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-4202673,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-8204360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19617914-9583724
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1932-6203
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
e6292
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19617914-Blotting, Western,
pubmed-meshheading:19617914-Carrier Proteins,
pubmed-meshheading:19617914-Case-Control Studies,
pubmed-meshheading:19617914-Female,
pubmed-meshheading:19617914-Folate Receptors, GPI-Anchored,
pubmed-meshheading:19617914-Humans,
pubmed-meshheading:19617914-Immunoassay,
pubmed-meshheading:19617914-Immunoprecipitation,
pubmed-meshheading:19617914-Ovarian Neoplasms,
pubmed-meshheading:19617914-Receptors, Cell Surface,
pubmed-meshheading:19617914-Tumor Markers, Biological
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pubmed:year |
2009
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pubmed:articleTitle |
Functional folate receptor alpha is elevated in the blood of ovarian cancer patients.
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pubmed:affiliation |
Department of Immunology, Mayo Clinic, Rochester, MN, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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