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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
8
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pubmed:dateCreated |
2009-7-30
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pubmed:abstractText |
The active metabolite of mycophenolate mofetil (MMF), mycophenolic acid, inhibits the activity of the target enzyme inosine monophosphate dehydrogenase (IMPDH). The aim of this study was to correlate eight different single nucleotide polymorphisms of the IMPDH type II gene to the activity of the IMPDH enzyme to explain between-patient differences in IMPDH activity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1744-6872
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
626-34
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pubmed:meshHeading |
pubmed-meshheading:19617864-Adult,
pubmed-meshheading:19617864-Area Under Curve,
pubmed-meshheading:19617864-Cohort Studies,
pubmed-meshheading:19617864-Female,
pubmed-meshheading:19617864-Genetic Variation,
pubmed-meshheading:19617864-Humans,
pubmed-meshheading:19617864-IMP Dehydrogenase,
pubmed-meshheading:19617864-Immunosuppressive Agents,
pubmed-meshheading:19617864-Kidney Failure, Chronic,
pubmed-meshheading:19617864-Kidney Transplantation,
pubmed-meshheading:19617864-Male,
pubmed-meshheading:19617864-Middle Aged,
pubmed-meshheading:19617864-Mycophenolic Acid,
pubmed-meshheading:19617864-Pharmacogenetics,
pubmed-meshheading:19617864-Polymorphism, Single Nucleotide,
pubmed-meshheading:19617864-Prospective Studies,
pubmed-meshheading:19617864-Treatment Outcome
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pubmed:year |
2009
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pubmed:articleTitle |
Interpatient variability in IMPDH activity in MMF-treated renal transplant patients is correlated with IMPDH type II 3757T > C polymorphism.
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pubmed:affiliation |
Department of Hospital Pharmacy, Erasmus University Medical Center, Rotterdam, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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