Linked Life Data

19616950

Source:http://linkedlifedata.com/resource/pubmed/id/19616950

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
2009-8-17
pubmed:abstractText
In higher eukaryotes, the vast majority of protein-coding genes contain introns that must be removed from precursor mRNA (pre-mRNA) with great precision by the spliceosome. Spliceosomes are massive RNA-protein macromolecular machines with >100 distinct components that assemble onto nascent transcripts and are released from the mRNA after splicing. A large and longstanding body of biochemical evidence indicates that the spliceosome is constructed de novo for each round of splicing in an ordered piece-by-piece stepwise assembly. More recently, exciting advances in intracellular imaging approaches are providing new clues to understand the dynamic organization of this and other multi-component molecular machines in the nucleus. The emerging data suggest that stochastic interactions between spliceosomal proteins originate intermediate complexes that localize in the close vicinity of active genes, thus contributing to increase the local availability of the individual pieces required for assembly of functional spliceosomes on newly synthesized pre-mRNA.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1879-3088
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
19
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
375-84
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The spliceosome: a self-organized macromolecular machine in the nucleus?
pubmed:affiliation
Instituto de Medicina Molecular, Faculdade de Medicina, Universidade de Lisboa, 1649-028 Lisboa, Portugal.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't