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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2009-9-21
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pubmed:abstractText |
There are currently no large animal models to study the biology of leukemia and development of novel antileukemia therapies. We have previously shown that dogs transplanted with homeobox B4 (HOXB4)-transduced autologous CD34(+) cells developed myeloid leukemia associated with HOXB4 overexpression. Here we describe the transmission, engraftment, and expansion of these canine leukemia cells into two genetically unrelated, immunosuppressed dogs.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1873-2399
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1157-66
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pubmed:dateRevised |
2010-12-3
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pubmed:meshHeading |
pubmed-meshheading:19616601-Accidents,
pubmed-meshheading:19616601-Animals,
pubmed-meshheading:19616601-Catheterization,
pubmed-meshheading:19616601-Cell Line, Tumor,
pubmed-meshheading:19616601-Disease Models, Animal,
pubmed-meshheading:19616601-Dogs,
pubmed-meshheading:19616601-Equipment Contamination,
pubmed-meshheading:19616601-Fluid Therapy,
pubmed-meshheading:19616601-Genes, Reporter,
pubmed-meshheading:19616601-Genetic Vectors,
pubmed-meshheading:19616601-Green Fluorescent Proteins,
pubmed-meshheading:19616601-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:19616601-Histocompatibility Antigens Class I,
pubmed-meshheading:19616601-Homeodomain Proteins,
pubmed-meshheading:19616601-Immunocompromised Host,
pubmed-meshheading:19616601-Immunosuppressive Agents,
pubmed-meshheading:19616601-Leukemia, Myeloid,
pubmed-meshheading:19616601-Minisatellite Repeats,
pubmed-meshheading:19616601-Neoplasm Transplantation,
pubmed-meshheading:19616601-Neoplastic Stem Cells,
pubmed-meshheading:19616601-Radiation Chimera,
pubmed-meshheading:19616601-Recombinant Fusion Proteins,
pubmed-meshheading:19616601-Transcription Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Transmission and expansion of HOXB4-induced leukemia in two immunosuppressed dogs: implications for a new canine leukemia model.
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pubmed:affiliation |
Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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