Linked Life Data

19616549

Source:http://linkedlifedata.com/resource/pubmed/id/19616549

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
15
pubmed:dateCreated
2009-8-4
pubmed:abstractText
Cardiolipin (CL) has recently been shown to provide an anchor and an essential activating platform for caspase-8 on mitochondria. We hypothesize that these platforms may correspond to "raft-like" microdomains, which have demonstrated to be detectable on mitochondrial membrane of cells undergoing apoptosis. The role for CL in "raft-like" microdomains could be to anchor caspase-8 at contact sites between inner and outer membranes, facilitating its self-activation, Bid cleavage and apoptosis execution. The role played by "raft-like" microdomains in the apoptotic program could introduce a new task in the pathogenetic studies on human diseases associated with cardiolipin dismetabolism.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1873-3468
pubmed:author
pubmed:issnType
Electronic
pubmed:day
6
pubmed:volume
583
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2447-50
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Cardiolipin-enriched raft-like microdomains are essential activating platforms for apoptotic signals on mitochondria.
pubmed:affiliation
Department of Experimental Medicine, Sapienza University of Rome, Rome, Italy. maurizio.sorice@uniroma1.it
pubmed:publicationType
Journal Article, Review