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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-9-15
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pubmed:abstractText |
Human tumors are characterized by the presence of cells that experience periodic episodes of hypoxia followed by reoxygenation. These cells are exposed to reactive oxygen species (ROS) upon reoxygenation and require adaptation to this stress by lowering ROS production or enhancing ROS-clearance for their survival. We hypothesized that autophagy, a lysosomal degradation pathway, may be involved in reducing ROS during periodic hypoxia through removal of ROS producing species.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1879-0887
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
411-6
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pubmed:meshHeading |
pubmed-meshheading:19616335-Analysis of Variance,
pubmed-meshheading:19616335-Anoxia,
pubmed-meshheading:19616335-Autophagy,
pubmed-meshheading:19616335-Blotting, Western,
pubmed-meshheading:19616335-Cell Death,
pubmed-meshheading:19616335-Cell Line, Tumor,
pubmed-meshheading:19616335-Cell Survival,
pubmed-meshheading:19616335-Chloroquine,
pubmed-meshheading:19616335-DNA, Mitochondrial,
pubmed-meshheading:19616335-Flow Cytometry,
pubmed-meshheading:19616335-Humans,
pubmed-meshheading:19616335-Oxidative Stress,
pubmed-meshheading:19616335-Probability,
pubmed-meshheading:19616335-Reactive Oxygen Species,
pubmed-meshheading:19616335-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:19616335-Tumor Cells, Cultured
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pubmed:year |
2009
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pubmed:articleTitle |
Autophagy is required during cycling hypoxia to lower production of reactive oxygen species.
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pubmed:affiliation |
Maastricht Radiation Oncology (MaastRo) Lab, GROW-School for Oncology and Developmental Biology, University of Maastricht, The Netherlands. Kasper.Rouschop@maastro.unimaas.nl
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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