Linked Life Data

19616069

Source:http://linkedlifedata.com/resource/pubmed/id/19616069

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-8-4
pubmed:abstractText
Fibroblast growth factor 2 (FGF2) is involved in hippocampus-dependent learning. In this study, the effects of FGF2 on the excitability were investigated in granule cells of rat dentate gyrus. Hippocampal slices were used to perform patch clamp recordings in granule cells. Extracellularly applied FGF2 early quenched the depolarization-induced repetitive firing, suggesting a decreased excitability under these conditions. Consistently, transient and sustained voltage-gated K(+) currents decreased in a dose-dependent manner, repolarization phase of action potential was slowed down, afterhyperpolarization was reduced, and membrane resistance was decreased. These effects were not mediated by tyrosine kinase FGF2 receptors. Moreover, an involvement of G protein signaling was ruled out, as well as an intracellular action of FGF2. Considering the relationship between FGF2 and hippocampal functions, the modulation of neuron excitability by activity-driven FGF2 release may be regarded as a part of a homeostatic mechanism of self-regulation of hippocampal activity.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1872-7972
pubmed:author
pubmed:issnType
Electronic
pubmed:day
25
pubmed:volume
462
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
203-6
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
FGF2 modulates the voltage-dependent K+ current and changes excitability of rat dentate gyrus granule cells.
pubmed:affiliation
Dipartimento di Scienze dell'Uomo, dell'Ambiente e della Natura-Sezione di Fisiologia, Università degli Studi di Urbino Carlo Bo, Urbino, Italy. carla.cuppini@uniurb.it
pubmed:publicationType
Journal Article, In Vitro