|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
16
|
|
pubmed:dateCreated |
2009-7-29
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|
pubmed:abstractText |
We describe the synthesis and characterization of two acetazolamide derivatives containing either a charged fluorophore or an albumin-binding moiety, which restrict binding to carbonic anhydrase IX and XII present on tumor cells. In vivo studies showed the preferentially targeting of tumor cells by the fluorescent acetazolamide derivative and the ability of the albumin-binding acetazolamide derivative to cause tumor retardation in a SK-RC-52 xenograft model of cancer.
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pubmed:language |
eng
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|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1464-3405
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:day |
15
|
|
pubmed:volume |
19
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
4851-6
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|
pubmed:meshHeading |
pubmed-meshheading:19615903-Acetamides,
pubmed-meshheading:19615903-Animals,
pubmed-meshheading:19615903-Antigens, Neoplasm,
pubmed-meshheading:19615903-Antineoplastic Agents,
pubmed-meshheading:19615903-Carbonic Anhydrase Inhibitors,
pubmed-meshheading:19615903-Carbonic Anhydrases,
pubmed-meshheading:19615903-Cell Line, Tumor,
pubmed-meshheading:19615903-Colorectal Neoplasms,
pubmed-meshheading:19615903-Fluorescent Dyes,
pubmed-meshheading:19615903-Humans,
pubmed-meshheading:19615903-Mice,
pubmed-meshheading:19615903-Mice, Nude,
pubmed-meshheading:19615903-Xenograft Model Antitumor Assays
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|
pubmed:year |
2009
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|
pubmed:articleTitle |
In vivo targeting of tumor-associated carbonic anhydrases using acetazolamide derivatives.
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|
pubmed:affiliation |
Department of Chemistry and Applied Biosciences, Institute of Pharmaceutical Sciences, ETH Zurich, CH-8093 Zurich, Switzerland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
