Linked Life Data

19615407

Source:http://linkedlifedata.com/resource/pubmed/id/19615407

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
2009-9-22
pubmed:abstractText
Peroxisome proliferator-activated receptor (PPAR)-beta/delta is a member of the PPAR nuclear hormone receptor family. The PPARs are a family of 3 ligand-activated transcription factors: PPARalpha (NR1C1), PPARbeta/delta (NR1C2), and PPARgamma (NR1C3). All the PPARs play important roles in the regulation of metabolic pathways, including those of lipid of biosynthesis and glucose metabolism, as well as in a variety of cell differentiation, proliferation, and apoptosis pathways. Recently, there has been a great deal of interest in the involvement of PPARs in the inflammatory processes. In particular, PPARalpha and PPARgamma inhibit the activation of inflammatory gene expression and can negatively interfere with pro-inflammatory transcription factor signalling pathways in vascular and inflammatory cells. In contrast, the roles of PPARbeta/delta regulating inflammation and immunity are only just emerging. This review will focus on these emerging roles of PPARbeta/delta in regulating inflammatory processes.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1879-016X
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
124
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
141-50
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Emerging roles of peroxisome proliferator-activated receptor-beta/delta in inflammation.
pubmed:affiliation
Translational Medicine and Therapeutics, William Harvey Research Institute, Barts and The London, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. d.bishop-bailey@qmul.ac.uk
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't