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rdf:type |
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lifeskim:mentions |
umls-concept:C0003123,
umls-concept:C0003741,
umls-concept:C0017262,
umls-concept:C0020663,
umls-concept:C0021753,
umls-concept:C0027893,
umls-concept:C0034693,
umls-concept:C0035696,
umls-concept:C0185117,
umls-concept:C1522673,
umls-concept:C2349975,
umls-concept:C2911684
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|
pubmed:issue |
6
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|
pubmed:dateCreated |
2009-9-29
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|
pubmed:abstractText |
Food intake is activated by hypothalamic orexigenic neuropeptide Y (NPY), which is mainly under the dual control of leptin and ghrelin. Rat adjuvant arthritis (AA), similarly as human rheumatoid arthritis, is associated with cachexia caused by yet unknown mechanisms. The aim of our study was to evaluate NPY expression in hypothalamic arcuate nuclei (nARC) under the conditions of AA-induced changes in leptin, ghrelin and adiponectin. Since IL-1beta is involved in the central induction of anorexia, we studied its expression in the nARC as well.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:issn |
1423-0216
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2009 S. Karger AG, Basel.
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pubmed:issnType |
Electronic
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
377-84
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pubmed:meshHeading |
pubmed-meshheading:19609086-Adiponectin,
pubmed-meshheading:19609086-Animals,
pubmed-meshheading:19609086-Anorexia,
pubmed-meshheading:19609086-Appetite,
pubmed-meshheading:19609086-Appetite Regulation,
pubmed-meshheading:19609086-Arcuate Nucleus,
pubmed-meshheading:19609086-Arthritis,
pubmed-meshheading:19609086-Disease Models, Animal,
pubmed-meshheading:19609086-Gene Expression Regulation,
pubmed-meshheading:19609086-Ghrelin,
pubmed-meshheading:19609086-Hypothalamo-Hypophyseal System,
pubmed-meshheading:19609086-Interleukin-1beta,
pubmed-meshheading:19609086-Leptin,
pubmed-meshheading:19609086-Male,
pubmed-meshheading:19609086-Neuropeptide Y,
pubmed-meshheading:19609086-RNA, Messenger,
pubmed-meshheading:19609086-Rats,
pubmed-meshheading:19609086-Rats, Inbred Lew,
pubmed-meshheading:19609086-Signal Transduction,
pubmed-meshheading:19609086-Up-Regulation
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pubmed:year |
2009
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pubmed:articleTitle |
Enhanced expressions of mRNA for neuropeptide Y and interleukin 1 beta in hypothalamic arcuate nuclei during adjuvant arthritis-induced anorexia in Lewis rats.
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pubmed:affiliation |
Department of Normal, Pathological, and Clinical Physiology, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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