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rdf:type |
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lifeskim:mentions |
umls-concept:C0002932,
umls-concept:C0003018,
umls-concept:C0021469,
umls-concept:C0031715,
umls-concept:C0033684,
umls-concept:C0067062,
umls-concept:C0220905,
umls-concept:C0373746,
umls-concept:C1140999,
umls-concept:C1417581,
umls-concept:C1423014,
umls-concept:C1709059,
umls-concept:C1711351,
umls-concept:C1801960,
umls-concept:C1963547
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pubmed:issue |
2
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pubmed:dateCreated |
2009-7-17
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pubmed:abstractText |
Vascular contraction is regulated by myosin light chain (MLC) phosphorylation. Inhibition of MLC phosphatase (MLCP) increases MLC phosphorylation for a given Ca(2+) concentration, and results in promoting myofilament Ca(2+) sensitivity. MLCP activity is mainly determined by protein kinase C (PKC) and Rho kinase through the phosphorylation of both PKC-potentiated inhibitory protein (CPI-17) and myosin phosphatase target subunit (MYPT1). We have previously demonstrated that sevoflurane inhibits PKC phosphorylation and membrane translocation of Rho kinase. This study was designed to investigate the effects of sevoflurane and isoflurane on CPI-17, MYPT1, and MLC phosphorylation in response to angiotensin II (Ang II) in rat aortic smooth muscle.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Anesthetics, Inhalation,
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin II,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflurane,
http://linkedlifedata.com/resource/pubmed/chemical/Methyl Ethers,
http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myosin Light Chains,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ppp1r12a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Ppp1r14a protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Protein Phosphatase 1,
http://linkedlifedata.com/resource/pubmed/chemical/Vasoconstrictor Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Vasodilator Agents,
http://linkedlifedata.com/resource/pubmed/chemical/sevoflurane
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1526-7598
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
109
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
412-7
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pubmed:meshHeading |
pubmed-meshheading:19608811-Anesthetics, Inhalation,
pubmed-meshheading:19608811-Angiotensin II,
pubmed-meshheading:19608811-Animals,
pubmed-meshheading:19608811-Aorta, Thoracic,
pubmed-meshheading:19608811-Isoflurane,
pubmed-meshheading:19608811-Isometric Contraction,
pubmed-meshheading:19608811-Kinetics,
pubmed-meshheading:19608811-Male,
pubmed-meshheading:19608811-Methyl Ethers,
pubmed-meshheading:19608811-Muscle, Smooth, Vascular,
pubmed-meshheading:19608811-Muscle Proteins,
pubmed-meshheading:19608811-Myosin Light Chains,
pubmed-meshheading:19608811-Phosphoproteins,
pubmed-meshheading:19608811-Phosphorylation,
pubmed-meshheading:19608811-Protein Phosphatase 1,
pubmed-meshheading:19608811-Rats,
pubmed-meshheading:19608811-Vasoconstrictor Agents,
pubmed-meshheading:19608811-Vasodilator Agents
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pubmed:year |
2009
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pubmed:articleTitle |
Volatile anesthetics inhibit angiotensin II-induced vascular contraction by modulating myosin light chain phosphatase inhibiting protein, CPI-17 and regulatory subunit, MYPT1 phosphorylation.
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pubmed:affiliation |
Department of Anesthesiology, Wakayama Medical University, Wakayama City 641-0012, Japan.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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