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pubmed:abstractText |
During the first line defense of an infected host, circulating neutrophils invade the inflamed tissue, whereas mature neutrophils from the bone marrow pool migrate into the blood circulation and from there reinforce tissue infiltration. The CXC chemokine CXCL8, also know as interleukin-8, is a potent attractant of neutrophils. Recently, we discovered a new natural post-translational modification of CXCL8, i.e. the deimination of arginine into citrulline by peptidylarginine deiminases.
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pubmed:affiliation |
Laboratory of Molecular Immunology, Rega Institute, K.U.Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium.
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