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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
39
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pubmed:dateCreated |
2009-8-17
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pubmed:abstractText |
To identify an adjuvant that enhances antibody responses in respiratory secretions to inactivated influenza virus vaccine (IVV), a comparison was made of responses to intranasal vaccinations of mice with IVV containing monophosphoryl lipid A (MPL), type I interferon (IFN) or cholera toxin B (CTB). Antibody in nasal secretions and lung wash fluids from mice was increased after vaccination and lung virus was significantly reduced after challenge to a similar level in each adjuvant group. Interferon was selected for a trial in humans. Trivalent inactivated influenza vaccine was given intranasally to healthy adult volunteers alone or with 1 million units (Mu) or 10 Mu of alpha interferon. Vaccinations were well tolerated but neither serum hemagglutination-inhibiting nor neutralizing antibody responses among the vaccine groups were significantly different. Similarly, neither neutralizing nor IgA antibody responses in nasal secretions were significantly different. Thus, despite exhibiting a significant adjuvant effect in mice, interferon did not exhibit an adjuvant effect for induction of antibody in respiratory secretions of humans to inactivated influenza virus vaccine given intranasally.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-10438868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-10738099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-10930676,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-11027803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-11483740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-11505461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-11738734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-11803086,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-12077267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-12559796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-15193382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-15790347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-16129526,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-16394001,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-16571878,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-16611561,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-16641287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-17280748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-17559990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-17707753,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-18602728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-2251874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-4184389,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-4303877,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-4320734,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-6609824,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-6619578,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-7998417,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19607949-8852406
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Cholera Toxin,
http://linkedlifedata.com/resource/pubmed/chemical/Influenza Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Lipid A,
http://linkedlifedata.com/resource/pubmed/chemical/Vaccines, Inactivated,
http://linkedlifedata.com/resource/pubmed/chemical/monophosphoryl lipid A
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
1873-2518
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
27
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pubmed:volume |
27
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
5344-8
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pubmed:dateRevised |
2010-9-27
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pubmed:meshHeading |
pubmed-meshheading:19607949-Adjuvants, Immunologic,
pubmed-meshheading:19607949-Administration, Intranasal,
pubmed-meshheading:19607949-Adolescent,
pubmed-meshheading:19607949-Adult,
pubmed-meshheading:19607949-Animals,
pubmed-meshheading:19607949-Antibodies, Viral,
pubmed-meshheading:19607949-Cholera Toxin,
pubmed-meshheading:19607949-Humans,
pubmed-meshheading:19607949-Immunity, Mucosal,
pubmed-meshheading:19607949-Influenza, Human,
pubmed-meshheading:19607949-Influenza A virus,
pubmed-meshheading:19607949-Influenza Vaccines,
pubmed-meshheading:19607949-Interferon Type I,
pubmed-meshheading:19607949-Lipid A,
pubmed-meshheading:19607949-Mice,
pubmed-meshheading:19607949-Mice, Inbred ICR,
pubmed-meshheading:19607949-Neutralization Tests,
pubmed-meshheading:19607949-Vaccines, Inactivated,
pubmed-meshheading:19607949-Young Adult
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pubmed:year |
2009
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pubmed:articleTitle |
Contrasting effects of type I interferon as a mucosal adjuvant for influenza vaccine in mice and humans.
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pubmed:affiliation |
Department of Molecular Virology & Microbiology, Baylor College of Medicine, One Baylor Plaza, MS BCM 280, Houston, TX, USA. ikirk@bcm.edu
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pubmed:publicationType |
Journal Article,
Comparative Study
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