Linked Life Data

19606947

Source:http://linkedlifedata.com/resource/pubmed/id/19606947

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2009-7-17
pubmed:abstractText
Alginate microspheres loaded with dexamethasone were prepared by the droplet generator technique. Important parameters affecting drug release, including initial drug content, the type of polyelectrolyte coating, and a combination of different ratios of coated and uncoated microspheres were investigated to achieve in vitro dexamethasone delivery with approximately zero order release kinetics, releasing up to 100% of entrapped drug within 1 month, wherein dexamethasone released at a steady rate of 4.83 microg/day after an initial burst release period. These findings imply that these polyelectrolyte-coated alginate microspheres show promise as release systems to improve biocompatibility and prolong lifetime of implantable glucose sensors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1521-0464
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
331-40
pubmed:dateRevised
2011-9-22
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release.
pubmed:affiliation
School of Biosciences and Bioengineering, IIT Bombay, Powai, Mumbai, India.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural