| pubmed-article:19605762 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0228174 | lld:lifeskim |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0025519 | lld:lifeskim |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0282636 | lld:lifeskim |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0497406 | lld:lifeskim |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0220931 | lld:lifeskim |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0086582 | lld:lifeskim |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0518031 | lld:lifeskim |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0439231 | lld:lifeskim |
| pubmed-article:19605762 | lifeskim:mentions | umls-concept:C0587107 | lld:lifeskim |
| pubmed-article:19605762 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:19605762 | pubmed:dateCreated | 2009-8-25 | lld:pubmed |
| pubmed-article:19605762 | pubmed:abstractText | Endurance training improves muscular and cardiovascular fitness, but the effect on cerebral oxygenation and metabolism remains unknown. We hypothesized that 3 mo of endurance training would reduce cerebral carbohydrate uptake with maintained cerebral oxygenation during submaximal exercise. Healthy overweight males were included in a randomized, controlled study (training: n = 10; control: n = 7). Arterial and internal jugular venous catheterization was used to determine concentration differences for oxygen, glucose, and lactate across the brain and the oxygen-carbohydrate index [molar uptake of oxygen/(glucose + (1/2) lactate); OCI], changes in mitochondrial oxygen tension (DeltaP(Mito)O(2)) and the cerebral metabolic rate of oxygen (CMRO(2)) were calculated. For all subjects, resting OCI was higher at the 3-mo follow-up (6.3 +/- 1.3 compared with 4.7 +/- 0.9 at baseline, mean +/- SD; P < 0.05) and coincided with a lower plasma epinephrine concentration (P < 0.05). Cerebral adaptations to endurance training manifested when exercising at 70% of maximal oxygen uptake (approximately 211 W). Before training, both OCI (3.9 +/- 0.9) and DeltaP(Mito)O(2) (-22 mmHg) decreased (P < 0.05), whereas CMRO(2) increased by 79 +/- 53 micromol x 100 x g(-1) min(-1) (P < 0.05). At the 3-mo follow-up, OCI (4.9 +/- 1.0) and DeltaP(Mito)O(2) (-7 +/- 13 mmHg) did not decrease significantly from rest and when compared with values before training (P < 0.05), CMRO(2) did not increase. This study demonstrates that endurance training attenuates the cerebral metabolic response to submaximal exercise, as reflected in a lower carbohydrate uptake and maintained cerebral oxygenation. | lld:pubmed |
| pubmed-article:19605762 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19605762 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19605762 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19605762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19605762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19605762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19605762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19605762 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19605762 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19605762 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:19605762 | pubmed:issn | 1522-1490 | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:RasmussenPP | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:NielsenH BHB | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:HomannP HPH | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:SecherN HNH | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:BrassardPP | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:StallknechtBB | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:SeifertTT | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:NordbyPP | lld:pubmed |
| pubmed-article:19605762 | pubmed:author | pubmed-author:WissenbergMM | lld:pubmed |
| pubmed-article:19605762 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19605762 | pubmed:volume | 297 | lld:pubmed |
| pubmed-article:19605762 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19605762 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19605762 | pubmed:pagination | R867-76 | lld:pubmed |
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| pubmed-article:19605762 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19605762 | pubmed:articleTitle | Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males. | lld:pubmed |
| pubmed-article:19605762 | pubmed:affiliation | Department of Anesthesia, Section of Systems Biology Research, The Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark. tseifert78@gmail.com | lld:pubmed |
| pubmed-article:19605762 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:19605762 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:19605762 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19605762 | lld:pubmed |
