Source:http://linkedlifedata.com/resource/pubmed/id/19605762
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2009-8-25
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| pubmed:abstractText |
Endurance training improves muscular and cardiovascular fitness, but the effect on cerebral oxygenation and metabolism remains unknown. We hypothesized that 3 mo of endurance training would reduce cerebral carbohydrate uptake with maintained cerebral oxygenation during submaximal exercise. Healthy overweight males were included in a randomized, controlled study (training: n = 10; control: n = 7). Arterial and internal jugular venous catheterization was used to determine concentration differences for oxygen, glucose, and lactate across the brain and the oxygen-carbohydrate index [molar uptake of oxygen/(glucose + (1/2) lactate); OCI], changes in mitochondrial oxygen tension (DeltaP(Mito)O(2)) and the cerebral metabolic rate of oxygen (CMRO(2)) were calculated. For all subjects, resting OCI was higher at the 3-mo follow-up (6.3 +/- 1.3 compared with 4.7 +/- 0.9 at baseline, mean +/- SD; P < 0.05) and coincided with a lower plasma epinephrine concentration (P < 0.05). Cerebral adaptations to endurance training manifested when exercising at 70% of maximal oxygen uptake (approximately 211 W). Before training, both OCI (3.9 +/- 0.9) and DeltaP(Mito)O(2) (-22 mmHg) decreased (P < 0.05), whereas CMRO(2) increased by 79 +/- 53 micromol x 100 x g(-1) min(-1) (P < 0.05). At the 3-mo follow-up, OCI (4.9 +/- 1.0) and DeltaP(Mito)O(2) (-7 +/- 13 mmHg) did not decrease significantly from rest and when compared with values before training (P < 0.05), CMRO(2) did not increase. This study demonstrates that endurance training attenuates the cerebral metabolic response to submaximal exercise, as reflected in a lower carbohydrate uptake and maintained cerebral oxygenation.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Blood Glucose,
http://linkedlifedata.com/resource/pubmed/chemical/Epinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Oxygen
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| pubmed:status |
MEDLINE
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| pubmed:month |
Sep
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| pubmed:issn |
1522-1490
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
297
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
R867-76
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| pubmed:meshHeading |
pubmed-meshheading:19605762-Adaptation, Physiological,
pubmed-meshheading:19605762-Adult,
pubmed-meshheading:19605762-Blood Glucose,
pubmed-meshheading:19605762-Brain,
pubmed-meshheading:19605762-Cerebrovascular Circulation,
pubmed-meshheading:19605762-Epinephrine,
pubmed-meshheading:19605762-Exercise,
pubmed-meshheading:19605762-Exercise Tolerance,
pubmed-meshheading:19605762-Hemodynamics,
pubmed-meshheading:19605762-Humans,
pubmed-meshheading:19605762-Lactic Acid,
pubmed-meshheading:19605762-Male,
pubmed-meshheading:19605762-Mitochondria,
pubmed-meshheading:19605762-Norepinephrine,
pubmed-meshheading:19605762-Overweight,
pubmed-meshheading:19605762-Oxygen,
pubmed-meshheading:19605762-Oxygen Consumption,
pubmed-meshheading:19605762-Physical Endurance,
pubmed-meshheading:19605762-Time Factors,
pubmed-meshheading:19605762-Ultrasonography, Doppler, Transcranial
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| pubmed:year |
2009
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| pubmed:articleTitle |
Cerebral oxygenation and metabolism during exercise following three months of endurance training in healthy overweight males.
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| pubmed:affiliation |
Department of Anesthesia, Section of Systems Biology Research, The Copenhagen Muscle Research Center, University of Copenhagen, Copenhagen, Denmark. tseifert78@gmail.com
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| pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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