|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
8
|
|
pubmed:dateCreated |
2009-8-4
|
|
pubmed:abstractText |
Genetic variants that contribute to the risk of psychiatric disorders may also affect normal variation in psychological function. Indeed, the behavioral effects of many genetic variants may be better understood as process-specific rather than disease-specific. A functional valine-to-methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with cognitive function and brain metabolic activity accompanying such tasks. Not all studies are consistent, and less is known about the effect of this polymorphism during development. The authors tested the hypothesis that a more informative COMT haplotype predicts normal cognitive development in a large population-based cohort of children enrolled in the Avon Longitudinal Study of Parents and Children.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-10022492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-10385681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-11237119,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-11254454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-11381111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-11806689,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-12402217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-12571159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-12595695,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-12668349,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-12716966,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15098000,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15124004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15290009,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15305167,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15457404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15668720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15821730,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15824744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-15962707,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-16786032,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-16835293,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17185601,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17202556,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17264842,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17357147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17477346,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17547583,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17667963,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17707347,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17805313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-17881525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-18006746,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-18037454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-18339359,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-18535998,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-7637804,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-8055944,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-8807664,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-9327997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605537-9707588
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
AIM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Aug
|
|
pubmed:issn |
1535-7228
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
166
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
909-16
|
|
pubmed:dateRevised |
2010-9-24
|
|
pubmed:meshHeading |
pubmed-meshheading:19605537-Catechol O-Methyltransferase,
pubmed-meshheading:19605537-Child,
pubmed-meshheading:19605537-Child Development,
pubmed-meshheading:19605537-Chromosome Mapping,
pubmed-meshheading:19605537-Chromosomes, Human, Pair 22,
pubmed-meshheading:19605537-Cognition,
pubmed-meshheading:19605537-Cohort Studies,
pubmed-meshheading:19605537-Female,
pubmed-meshheading:19605537-Gene Frequency,
pubmed-meshheading:19605537-Genetic Variation,
pubmed-meshheading:19605537-Genotype,
pubmed-meshheading:19605537-Haplotypes,
pubmed-meshheading:19605537-Humans,
pubmed-meshheading:19605537-Intelligence Tests,
pubmed-meshheading:19605537-Linear Models,
pubmed-meshheading:19605537-Linkage Disequilibrium,
pubmed-meshheading:19605537-Longitudinal Studies,
pubmed-meshheading:19605537-Male,
pubmed-meshheading:19605537-Methionine,
pubmed-meshheading:19605537-Neuropsychological Tests,
pubmed-meshheading:19605537-Polymorphism, Single Nucleotide,
pubmed-meshheading:19605537-Valine
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children.
|
|
pubmed:affiliation |
Department of Psychiatryand the Centre for Family Research, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK. jhb32@cam.ac.uk
|
|
pubmed:publicationType |
Journal Article
|
