Source:http://linkedlifedata.com/resource/pubmed/id/19605528
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
9
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pubmed:dateCreated |
2009-8-21
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pubmed:abstractText |
Type 2 diabetes is highly prevalent in North America and is associated with increased risk of cardiovascular disease (CVD). Evidence supports a role for soy protein in the reduction of serum lipids related to CVD risk; however, few studies have focused on adults with type 2 diabetes who are not on lipid-lowering medications and/or do not have diabetic complications. The purpose of this study was to determine the effect of soy protein isolate (SPI) consumption on serum lipids in adults with diet-controlled type 2 diabetes. Using a double-blind, randomized, crossover, placebo-controlled intervention study design, adults with diet-controlled type 2 diabetes (n = 29) consumed SPI (80 mg/d aglycone isoflavones) or milk protein isolate (MPI) for 57 d each separated by a 28-d washout period. Twenty-four-hour urine samples were collected on d 54-56 of each treatment for analysis of isoflavones and blood was collected on d 1 and 57 of each treatment and analyzed for serum lipids and apolipoproteins. SPI consumption increased urinary isoflavones compared with MPI. SPI consumption reduced serum LDL cholesterol (P = 0.04), LDL cholesterol:HDL cholesterol (P = 0.02), and apolipoprotein B:apolipoprotein A-I (P = 0.05) compared with MPI. SPI did not affect serum total cholesterol, HDL cholesterol, triacylglycerol, apolipoprotein B, or apolipoprotein A-I. These data demonstrate that consumption of soy protein can modulate some serum lipids in a direction beneficial for CVD risk in adults with type 2 diabetes.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoprotein A-I,
http://linkedlifedata.com/resource/pubmed/chemical/Apolipoproteins B,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, HDL,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol, LDL,
http://linkedlifedata.com/resource/pubmed/chemical/Isoflavones,
http://linkedlifedata.com/resource/pubmed/chemical/Soybean Proteins
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
1541-6100
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pubmed:author | |
pubmed:issnType |
Electronic
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pubmed:volume |
139
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1700-6
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pubmed:meshHeading |
pubmed-meshheading:19605528-Adult,
pubmed-meshheading:19605528-Animals,
pubmed-meshheading:19605528-Apolipoprotein A-I,
pubmed-meshheading:19605528-Apolipoproteins B,
pubmed-meshheading:19605528-Cattle,
pubmed-meshheading:19605528-Cholesterol, HDL,
pubmed-meshheading:19605528-Cholesterol, LDL,
pubmed-meshheading:19605528-Cross-Over Studies,
pubmed-meshheading:19605528-Diabetes Mellitus, Type 2,
pubmed-meshheading:19605528-Diet,
pubmed-meshheading:19605528-Double-Blind Method,
pubmed-meshheading:19605528-Female,
pubmed-meshheading:19605528-Humans,
pubmed-meshheading:19605528-Isoflavones,
pubmed-meshheading:19605528-Lipid Metabolism,
pubmed-meshheading:19605528-Male,
pubmed-meshheading:19605528-Milk,
pubmed-meshheading:19605528-Soybean Proteins
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pubmed:year |
2009
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pubmed:articleTitle |
Soy protein reduces serum LDL cholesterol and the LDL cholesterol:HDL cholesterol and apolipoprotein B:apolipoprotein A-I ratios in adults with type 2 diabetes.
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pubmed:affiliation |
Department of Human Health and Nutritional Sciences, University of Guelph, Guelph, ON, Canada N1G 2W1.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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