Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
19
pubmed:dateCreated
2009-9-9
pubmed:databankReference
pubmed:abstractText
In most human immunodeficiency virus type 1 (HIV-1)-infected individuals who achieve viral loads of <50 copies/ml during highly active antiretroviral therapy (HAART), low levels of plasma virus remain detectable for years by ultrasensitive methods. The relative contributions of ongoing virus replication and virus production from HIV-1 reservoirs to persistent low-level viremia during HAART remain controversial. HIV-1 vaccination of HAART-treated individuals provides a model for examining low-level viremia, as immunizations may facilitate virus replication and sequence evolution. In a phase 1 trial of modified vaccinia virus Ankara/fowlpox virus-based HIV-1 vaccines in 20 HIV-infected young adults receiving HAART, we assessed the prevalence of low-level viremia and sequence evolution, using ultrasensitive viral load (<6.5 copies/ml) and genotyping (five-copy sensitivity) assays. Viral evolution, consisting of new drug resistance mutations and novel amino acid changes within a relevant HLA-restricted allele (e.g., methionine, isoleucine, glutamine, or arginine for leucine at position 205 of RT), was found in 1 and 3 of 20 subjects, respectively. Sequence evolution was significantly correlated with levels of viremia of between 6.5 and <50 copies/ml (P = 0.03) and was more likely to occur within epitopes presented by relevant HLA alleles (P < 0.001). These findings suggest that ongoing virus replication contributes to low-level viremia in patients on HAART and that this ongoing replication is subject to CD8(+) T-cell selective pressures.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-10341273, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-10502799, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-10553788, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-11044070, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-11238990, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-11448280, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-11448283, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-11588503, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-11986671, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-12525599, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-12931558, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-14505932, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-14512569, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-14530136, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-14694128, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-14707789, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-15073683, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-15280502, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-15472857, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-15713771, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-16014925, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-16061962, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-16682496, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-16775332, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-16820070, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-16828172, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-16890832, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-17135583, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-17411338, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-17411371, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-17488738, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-17538883, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-17926649, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-18332425, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-18476292, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-18552857, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-18940219, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-18986246, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-19470482, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-2480604, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-7536421, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-9045880, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-9144290, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-9225023, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-9768618, http://linkedlifedata.com/resource/pubmed/commentcorrection/19605490-9918953
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1098-5514
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
9731-42
pubmed:dateRevised
2010-9-27
pubmed:meshHeading
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