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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
40
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pubmed:dateCreated |
2009-10-5
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pubmed:databankReference |
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pubmed:abstractText |
CD8(+) T-cells specific for MART-1-(26-35), a dominant melanoma epitope restricted by human leukocyte antigen (HLA)-A*0201, are exceptionally common in the naive T-cell repertoire. Remarkably, the TRAV12-2 gene is used to encode the T-cell receptor alpha (TCRalpha) chain in >87% of these T-cells. Here, the molecular basis for this genetic bias is revealed from the structural and thermodynamic properties of an archetypal TRAV12-2-encoded TCR complexed to the clinically relevant heteroclitic peptide, ELAGIGILTV, bound to HLA-A*0201 (A2-ELA). Unusually, the TRAV12-2 germ line-encoded regions of the TCR dominate the major atomic contacts with the peptide at the TCR/A2-ELA interface. This "innate" pattern of antigen recognition probably explains the unique characteristics and extraordinary frequencies of CD8(+) T-cell responses to this epitope.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Neoplasm,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A*02:01 antigen,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/HLA-A2 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/Immunodominant Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/MART-1 Antigen,
http://linkedlifedata.com/resource/pubmed/chemical/MLANA protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Neoplasm Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Antigen, T-Cell
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1083-351X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
2
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pubmed:volume |
284
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
27281-9
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19605354-Amino Acid Sequence,
pubmed-meshheading:19605354-Antigens, Neoplasm,
pubmed-meshheading:19605354-CD8-Positive T-Lymphocytes,
pubmed-meshheading:19605354-Germ Cells,
pubmed-meshheading:19605354-HLA-A Antigens,
pubmed-meshheading:19605354-HLA-A2 Antigen,
pubmed-meshheading:19605354-Humans,
pubmed-meshheading:19605354-Immunity, Innate,
pubmed-meshheading:19605354-Immunodominant Epitopes,
pubmed-meshheading:19605354-MART-1 Antigen,
pubmed-meshheading:19605354-Melanoma,
pubmed-meshheading:19605354-Models, Molecular,
pubmed-meshheading:19605354-Neoplasm Proteins,
pubmed-meshheading:19605354-Protein Conformation,
pubmed-meshheading:19605354-Receptors, Antigen, T-Cell,
pubmed-meshheading:19605354-Solubility,
pubmed-meshheading:19605354-Substrate Specificity,
pubmed-meshheading:19605354-Thermodynamics
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pubmed:year |
2009
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pubmed:articleTitle |
Germ line-governed recognition of a cancer epitope by an immunodominant human T-cell receptor.
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pubmed:affiliation |
Department of Infection, Immunity, and Biochemistry, Henry Wellcome Building, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, United Kingdom.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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