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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-7-16
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pubmed:abstractText |
To investigate the -1291 C/G promoter polymorphism (rs1800544) of the adrenergic alpha-2A receptor (ADRA2A) with clozapine-/olanzapine-induced weight gain in European-Americans and African-Americans. The alpha-adrenergic receptors inhibit lipolysis in the adipose tissue and are involved in weight gain regulation. Moreover, two previous studies indicated an association with antipsychotic-induced weight gain with the same polymorphism in Asian populations.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1744-8042
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1169-76
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:19604092-Adult,
pubmed-meshheading:19604092-African Americans,
pubmed-meshheading:19604092-Antipsychotic Agents,
pubmed-meshheading:19604092-Double-Blind Method,
pubmed-meshheading:19604092-European Continental Ancestry Group,
pubmed-meshheading:19604092-Female,
pubmed-meshheading:19604092-Genome-Wide Association Study,
pubmed-meshheading:19604092-Humans,
pubmed-meshheading:19604092-Male,
pubmed-meshheading:19604092-Middle Aged,
pubmed-meshheading:19604092-Polymorphism, Genetic,
pubmed-meshheading:19604092-Prospective Studies,
pubmed-meshheading:19604092-Receptors, Adrenergic, alpha-2,
pubmed-meshheading:19604092-Weight Gain
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pubmed:year |
2009
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pubmed:articleTitle |
Association of the alpha 2A adrenergic receptor -1291C/G polymorphism and antipsychotic-induced weight gain in European-Americans.
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pubmed:affiliation |
Charité University Medicine Berlin, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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