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pubmed-article:19604089pubmed:abstractTextA recent study found that variation in camptothecin pharmacodynamic genes (TOP1, PARP1, TDP1 and XRCC1) correlated with efficacy and risk of neutropenia in irinotecan-treated cancer patients (median dose: 180 mg/m2), which suggests that these genes might predict outcomes to irinotecan-based therapies. The present study was conducted to evaluate previous gene associations using an independent sample of patients receiving irinotecan.lld:pubmed
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pubmed-article:19604089pubmed:articleTitlePharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.lld:pubmed
pubmed-article:19604089pubmed:affiliationUNC Institute for Pharmacogenomics & Individualized Therapy, University of North Carolina, Genetic Medicine Building, Chapel Hill, NC 27599-7360, USA. janelle_hoskins@unc.edulld:pubmed
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