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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2009-7-16
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pubmed:abstractText |
A recent study found that variation in camptothecin pharmacodynamic genes (TOP1, PARP1, TDP1 and XRCC1) correlated with efficacy and risk of neutropenia in irinotecan-treated cancer patients (median dose: 180 mg/m2), which suggests that these genes might predict outcomes to irinotecan-based therapies. The present study was conducted to evaluate previous gene associations using an independent sample of patients receiving irinotecan.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-10744089,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-11006366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-11156391,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-11791212,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-11815397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-11990381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-14576839,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-14699148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15007088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15175435,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15280927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15286088,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15297419,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15342424,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15379698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15469406,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15494395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15705867,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-15970793,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-16030121,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-16271446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-16508634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-17184208,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-17728214,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-18347181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-9653159,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19604089-9739812
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1744-8042
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1139-46
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pubmed:dateRevised |
2011-6-14
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pubmed:meshHeading |
pubmed-meshheading:19604089-Adult,
pubmed-meshheading:19604089-Aged,
pubmed-meshheading:19604089-Aged, 80 and over,
pubmed-meshheading:19604089-Camptothecin,
pubmed-meshheading:19604089-Cohort Studies,
pubmed-meshheading:19604089-Dose-Response Relationship, Drug,
pubmed-meshheading:19604089-Female,
pubmed-meshheading:19604089-Haplotypes,
pubmed-meshheading:19604089-Humans,
pubmed-meshheading:19604089-Male,
pubmed-meshheading:19604089-Middle Aged,
pubmed-meshheading:19604089-Neoplasms,
pubmed-meshheading:19604089-Neutropenia,
pubmed-meshheading:19604089-Polymorphism, Genetic,
pubmed-meshheading:19604089-Risk Factors
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pubmed:year |
2009
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pubmed:articleTitle |
Pharmacodynamic genes do not influence risk of neutropenia in cancer patients treated with moderately high-dose irinotecan.
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pubmed:affiliation |
UNC Institute for Pharmacogenomics & Individualized Therapy, University of North Carolina, Genetic Medicine Building, Chapel Hill, NC 27599-7360, USA. janelle_hoskins@unc.edu
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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