Linked Life Data

1960249

Source:http://linkedlifedata.com/resource/pubmed/id/1960249

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1992-1-3
pubmed:abstractText
An abbreviated treatment with a chlorhexidine-containing varnish was compared with a similar treatment with a placebo varnish and with a prophylaxis alone for its effects on the numbers of detectable salivary mutants streptococci in 51 adults. The varnishes, applied once weekly for four weeks, were held in place with a covering layer of either of two polyurethane sealants (FluorProtector or Adhesit). On the first appointment, the varnish-sealant combination was applied to all tooth surfaces, but on succeeding appointments only the occlusal and approximal surfaces were covered. The chlorhexidine varnish, covered with either sealant, reduced the salivary mutans streptococci by an average of 3 logs (99.9%) in all of the 20 subjects treated, and below detectable levels for at least four weeks in nine of them. In the groups receiving placebo varnish-sealant combinations, the mean log number of mutans streptococci of the subjects was reduced only by approximately 0.5 log (32%), and none of the subjects experienced loss of their detectable mutans streptococci for four weeks, although one subject did so for three weeks. No significant difference between the effects of the two polyurethane sealants was observed. Treatment with a single prophylaxis had no effect on mutans streptococcus levels. Subjects treated with chlorhexidine varnish also experienced an increase in S. sanguis and a small decrease in yeasts. Loss of detectable mutans streptococci did not cause changes in the numbers of other micro-organisms examined, beyond those observed with chlorhexidine varnish treatment alone.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
D
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0022-0345
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1401-8
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed-meshheading:1960249-Acrylic Resins, pubmed-meshheading:1960249-Adult, pubmed-meshheading:1960249-Analysis of Variance, pubmed-meshheading:1960249-Anti-Infective Agents, Local, pubmed-meshheading:1960249-Chlorhexidine, pubmed-meshheading:1960249-Colony Count, Microbial, pubmed-meshheading:1960249-Composite Resins, pubmed-meshheading:1960249-DMF Index, pubmed-meshheading:1960249-Dental Caries, pubmed-meshheading:1960249-Dental Materials, pubmed-meshheading:1960249-Double-Blind Method, pubmed-meshheading:1960249-Drug Combinations, pubmed-meshheading:1960249-Female, pubmed-meshheading:1960249-Fluorides, Topical, pubmed-meshheading:1960249-Humans, pubmed-meshheading:1960249-Male, pubmed-meshheading:1960249-Polyurethanes, pubmed-meshheading:1960249-Saliva, pubmed-meshheading:1960249-Silanes, pubmed-meshheading:1960249-Streptococcus mutans
pubmed:year
1991
pubmed:articleTitle
Clinical trial in adults of an antimicrobial varnish for reducing mutans streptococci.
pubmed:affiliation
Faculty of Dentistry, University of Toronto, Ontario, Canada.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't