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rdf:type |
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lifeskim:mentions |
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pubmed:dateCreated |
2009-7-28
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pubmed:abstractText |
Cisplatin mediates its antineoplastic activity by formation of distinct DNA intrastrand cross links. The clinical efficacy and desirable dose escalations of cisplatin are restricted by the accumulation of DNA lesions in dorsal root ganglion (DRG) cells leading to sensory polyneuropathy (PNP). We investigated in a mouse model by which mechanism recombinant erythropoietin (rhEPO) protects the peripheral nervous system from structural and functional damage caused by cisplatin treatment with special emphasis on DNA damage burden.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602296-10381501,
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http://linkedlifedata.com/resource/pubmed/commentcorrection/19602296-9733516
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
1471-2202
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pubmed:author |
pubmed-author:DienerHans-ChristophHC,
pubmed-author:DzagnidzeAnnaA,
pubmed-author:EgenspergerRupertR,
pubmed-author:KatsaravaZazaZ,
pubmed-author:KribbenAndreasA,
pubmed-author:LiedertBerndB,
pubmed-author:LimmrothVolkerV,
pubmed-author:ObermannMarkM,
pubmed-author:SchäfersMariaM,
pubmed-author:ThomaleJuergenJ,
pubmed-author:YoonMin-SukMS
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pubmed:issnType |
Electronic
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pubmed:volume |
10
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
77
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:19602296-Animals,
pubmed-meshheading:19602296-Antineoplastic Agents,
pubmed-meshheading:19602296-Cisplatin,
pubmed-meshheading:19602296-DNA Damage,
pubmed-meshheading:19602296-Erythropoietin,
pubmed-meshheading:19602296-Ganglia, Spinal,
pubmed-meshheading:19602296-Immunohistochemistry,
pubmed-meshheading:19602296-Male,
pubmed-meshheading:19602296-Mice,
pubmed-meshheading:19602296-Mice, Inbred C57BL,
pubmed-meshheading:19602296-Microscopy, Electron, Transmission,
pubmed-meshheading:19602296-Mitochondria,
pubmed-meshheading:19602296-Myelin Sheath,
pubmed-meshheading:19602296-Neural Conduction,
pubmed-meshheading:19602296-Neuroprotective Agents,
pubmed-meshheading:19602296-Pain Measurement,
pubmed-meshheading:19602296-Polyneuropathies,
pubmed-meshheading:19602296-Recombinant Proteins,
pubmed-meshheading:19602296-Sciatic Nerve
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pubmed:year |
2009
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pubmed:articleTitle |
Erythropoietin overrides the triggering effect of DNA platination products in a mouse model of cisplatin-induced neuropathy.
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pubmed:affiliation |
Department of Neurology, University of Duisburg-Essen, Essen, Germany. Min-Suk.Yoon@uni-due.de
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pubmed:publicationType |
Journal Article
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