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pubmed-article:19602285pubmed:abstractTextThe Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including malaria, tuberculosis, bacteremia, and invasive pneumococal disease in heterozygous mutation carriers.lld:pubmed
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pubmed-article:19602285pubmed:articleTitleLow frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy.lld:pubmed
pubmed-article:19602285pubmed:affiliationInstitute of Medical Microbiology and Hygiene, Charité - University Medical Center Berlin, Germany. lutz.hamann@charite.delld:pubmed
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