|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2009-7-29
|
|
pubmed:abstractText |
The Toll-like receptors (TLRs) mediate innate immunity to various pathogens. A mutation (S180L) in the TLR downstream signal transducer TIRAP has recently been reported to be common in Europeans and Africans and to roughly half the risks of heterogeneous infectious diseases including malaria, tuberculosis, bacteremia, and invasive pneumococal disease in heterozygous mutation carriers.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-12447441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-12682500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-15623512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-15682975,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-15766650,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-16001361,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-16138104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-16362079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-16371473,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-16779724,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-16807108,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-17135446,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-17261807,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-17272492,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-17289997,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-17322885,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-17579034,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-17996048,
http://linkedlifedata.com/resource/pubmed/commentcorrection/19602285-18305471
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2350
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
10
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
65
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:19602285-Adolescent,
pubmed-meshheading:19602285-Adult,
pubmed-meshheading:19602285-African Continental Ancestry Group,
pubmed-meshheading:19602285-Aged,
pubmed-meshheading:19602285-Case-Control Studies,
pubmed-meshheading:19602285-Female,
pubmed-meshheading:19602285-Gene Frequency,
pubmed-meshheading:19602285-Genetic Predisposition to Disease,
pubmed-meshheading:19602285-Ghana,
pubmed-meshheading:19602285-Heterozygote,
pubmed-meshheading:19602285-Humans,
pubmed-meshheading:19602285-Leprosy,
pubmed-meshheading:19602285-Malaria, Falciparum,
pubmed-meshheading:19602285-Male,
pubmed-meshheading:19602285-Membrane Glycoproteins,
pubmed-meshheading:19602285-Middle Aged,
pubmed-meshheading:19602285-Polymorphism, Single Nucleotide,
pubmed-meshheading:19602285-Pregnancy,
pubmed-meshheading:19602285-Receptors, Interleukin-1,
pubmed-meshheading:19602285-Sepsis,
pubmed-meshheading:19602285-Young Adult
|
|
pubmed:year |
2009
|
|
pubmed:articleTitle |
Low frequency of the TIRAP S180L polymorphism in Africa, and its potential role in malaria, sepsis, and leprosy.
|
|
pubmed:affiliation |
Institute of Medical Microbiology and Hygiene, Charité - University Medical Center Berlin, Germany. lutz.hamann@charite.de
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
