Linked Life Data

19601884

Source:http://linkedlifedata.com/resource/pubmed/id/19601884

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2009-7-15
pubmed:abstractText
C3a and C5a, the small (approximately 10KDa) cleavage fragments released by complement activation, are potent mediators of inflammation. They are anaphylatoxins and act as cell activators with nanomolar affinity, exerting their functions through binding to specific receptors (C3aR and C5aR or C5L2 respectively). Recent studies suggest that locally generated complement effector molecules including C3a and C5a contribute to pathological processes in inflammatory and immunological diseases as well as adaptive immune response besides its host defence mechanism. Targeting the receptors and/or their ligands can reduce undesired inflammatory responses and tissue damage in certain pathological conditions. In this article we describe the recent developments in this important area and focus on the role of C3a/C5a in inflammatory and autoimmune diseases and in adaptive immune responses.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
2212-4055
pubmed:author
pubmed:issnType
Electronic
pubmed:volume
8
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-46
pubmed:dateRevised
2011-11-10
pubmed:meshHeading
pubmed:year
2009
pubmed:articleTitle
The role of anaphylatoxins C3a and C5a in regulating innate and adaptive immune responses.
pubmed:affiliation
Complement Laboratory, MRC Centre for Transplantation, King's College London, School of Medicine at Guy's Hospital, London SE1 9RT, UK.
pubmed:publicationType
Journal Article, Review, Research Support, Non-U.S. Gov't