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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2009-7-15
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pubmed:abstractText |
Recent evidence has shown that after the initial occlusion, a large portion of stroke patients achieve some degree of reperfusion either through collateral circulation or clot dissolution. However, it appears that this reperfusion may lead to increased inflammation-induced damage. Even though the exact mechanism of this secondary injury is unclear, several experimental studies have indicated an intimate connection between complement and this secondary form of damage. We review the available literature and attempt to identify promising clinical therapeutic targets.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1570-1611
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pubmed:author |
pubmed-author:AriasEric JEJ,
pubmed-author:ConnollyE SanderES,
pubmed-author:DucruetAndrew FAF,
pubmed-author:GarrettMatthew CMC,
pubmed-author:HassidBenjaminB,
pubmed-author:KimGrace HGH,
pubmed-author:KomotarRicardo JRJ,
pubmed-author:MackWilliam JWJ,
pubmed-author:MerkowMaxwell BMB,
pubmed-author:MoccoJJ,
pubmed-author:OttenMarc LML,
pubmed-author:StarkeRobert MRM,
pubmed-author:SughrueMichael EME
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
287-92
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pubmed:meshHeading |
pubmed-meshheading:19601853-Animals,
pubmed-meshheading:19601853-Brain,
pubmed-meshheading:19601853-Complement Activation,
pubmed-meshheading:19601853-Complement Inactivating Agents,
pubmed-meshheading:19601853-Disease Models, Animal,
pubmed-meshheading:19601853-Humans,
pubmed-meshheading:19601853-Models, Biological,
pubmed-meshheading:19601853-Neurogenesis,
pubmed-meshheading:19601853-Reperfusion Injury,
pubmed-meshheading:19601853-Stroke
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pubmed:year |
2009
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pubmed:articleTitle |
The complement cascade: new avenues in stroke therapy.
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pubmed:affiliation |
Department of Neurological Surgery, Columbia University, New York, NY 10011, USA. rjk2103@columbia.edu
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pubmed:publicationType |
Journal Article,
Review
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