| pubmed-article:19597998 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C0037083 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C0439851 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C1710082 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C1552596 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:19597998 | lifeskim:mentions | umls-concept:C1947931 | lld:lifeskim |
| pubmed-article:19597998 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:19597998 | pubmed:dateCreated | 2009-9-16 | lld:pubmed |
| pubmed-article:19597998 | pubmed:abstractText | It is well established that Toll-like receptors (TLRs) play a critical role in the generation of innate immune responses and thereby also play an important, indirect role in the initiation of subsequent adaptive T cell responses. However, T cells also express certain TLRs, and we have focused on the physiological importance of direct TLR signaling in T cells. TLRs can function as co-stimulatory receptors that complement TCR-induced signals to enhance effector T cell proliferation, survival and cytokine production. We also found that TLR signaling pathways in T cells are required for the effective clonal expansion of antigen-specific T cells during infection in vivo. Thus, the importance of TLRs in T cell-mediated immunity reflects both T cell-extrinsic and T cell-intrinsic components, which warrants a reconsideration of the dogma that restricts germ-line encoded pattern recognition to cells of the innate immune system. | lld:pubmed |
| pubmed-article:19597998 | pubmed:language | eng | lld:pubmed |
| pubmed-article:19597998 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19597998 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:19597998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19597998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19597998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19597998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19597998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19597998 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:19597998 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:19597998 | pubmed:issn | 1559-0755 | lld:pubmed |
| pubmed-article:19597998 | pubmed:author | pubmed-author:TurkaLaurence... | lld:pubmed |
| pubmed-article:19597998 | pubmed:author | pubmed-author:TaylorDevon... | lld:pubmed |
| pubmed-article:19597998 | pubmed:author | pubmed-author:RahmanAdeeb... | lld:pubmed |
| pubmed-article:19597998 | pubmed:issnType | Electronic | lld:pubmed |
| pubmed-article:19597998 | pubmed:volume | 45 | lld:pubmed |
| pubmed-article:19597998 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:19597998 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:19597998 | pubmed:pagination | 25-36 | lld:pubmed |
| pubmed-article:19597998 | pubmed:meshHeading | pubmed-meshheading:19597998... | lld:pubmed |
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| pubmed-article:19597998 | pubmed:meshHeading | pubmed-meshheading:19597998... | lld:pubmed |
| pubmed-article:19597998 | pubmed:year | 2009 | lld:pubmed |
| pubmed-article:19597998 | pubmed:articleTitle | The contribution of direct TLR signaling to T cell responses. | lld:pubmed |
| pubmed-article:19597998 | pubmed:affiliation | Department of Medicine and Immunology Graduate Group, University of Pennsylvania, 111 Clinical Research Building, 415 Curie Boulevard, Philadelphia, PA 19104, USA. | lld:pubmed |
| pubmed-article:19597998 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19597998 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:19597998 | lld:pubmed |
