Source:http://linkedlifedata.com/resource/pubmed/id/19597416
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
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| pubmed:dateCreated |
2010-2-10
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| pubmed:abstractText |
Peripheral T-cell lymphoma (PTCL) is generally characterized by poor prognosis after conventional chemotherapy compared with aggressive B-cell lymphoma. To elucidate the role of high-dose chemotherapy (HDCT) with auto-SCT, we retrospectively analyzed the outcomes of 39 patients with PTCL who received HDCT and auto-SCT between 1990 and 2005. Eleven patients were histologically typed as angioimmunoblastic, nine as anaplastic large-cell lymphoma, seven as natural killer/T-cell lymphoma and twelve as PTCL unspecified. Clinical conditions at transplantation were complete response (CR) in 27 patients and non-CR in 12 patients. Thirty-two patients received a pre-transplant conditioning regimen (MCEC) comprising ranimustine, carboplatin, etoposide and CY, and seven did other TBI-based regimens. Rapid engraftment was obtained in all cases, and transplant-related death was not seen. An estimated 5-year OS was 62.1% with a median follow-up of 78 months. The 5-year OS was significantly higher in patients transplanted during complete response than in those during other disease status (71.4% vs 27.3%, P=0.046). HDCT supported by auto-SCT may therefore be effective as consolidation in CR for PTCL treatment.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Feb
|
| pubmed:issn |
1476-5365
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| pubmed:author |
pubmed-author:AkashiKK,
pubmed-author:EtoTT,
pubmed-author:FukudaTT,
pubmed-author:HaradaMM,
pubmed-author:HaradaNN,
pubmed-author:HenzanHH,
pubmed-author:KamezakiKK,
pubmed-author:KamimuraTT,
pubmed-author:KatoKK,
pubmed-author:MiyamotoTT,
pubmed-author:NagafujiKK,
pubmed-author:NumataAA,
pubmed-author:OconSS,
pubmed-author:OhnoYY,
pubmed-author:TakaseKK,
pubmed-author:TakenakaKK,
pubmed-author:TanimotoTT,
pubmed-author:TeshimaTT
|
| pubmed:issnType |
Electronic
|
| pubmed:volume |
45
|
| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
311-6
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| pubmed:meshHeading |
pubmed-meshheading:19597416-Adolescent,
pubmed-meshheading:19597416-Adult,
pubmed-meshheading:19597416-Aged,
pubmed-meshheading:19597416-Antineoplastic Combined Chemotherapy Protocols,
pubmed-meshheading:19597416-Female,
pubmed-meshheading:19597416-Humans,
pubmed-meshheading:19597416-Japan,
pubmed-meshheading:19597416-Lymphoma, T-Cell, Peripheral,
pubmed-meshheading:19597416-Male,
pubmed-meshheading:19597416-Middle Aged,
pubmed-meshheading:19597416-Peripheral Blood Stem Cell Transplantation,
pubmed-meshheading:19597416-Retrospective Studies,
pubmed-meshheading:19597416-Treatment Outcome
|
| pubmed:year |
2010
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| pubmed:articleTitle |
Long-term outcomes of autologous PBSCT for peripheral T-cell lymphoma: retrospective analysis of the experience of the Fukuoka BMT group.
|
| pubmed:affiliation |
Department of Hematology, Hamanomachi Hospital, Fukuoka, Japan.
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| pubmed:publicationType |
Journal Article
|