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pubmed:abstractText |
In patients with left ventricular infarction or dilatation, leaflet tethering by displaced papillary muscles frequently induces mitral regurgitation, which doubles mortality. Little is known about the biological potential of the mitral valve (MV) to compensate for ventricular remodeling. We tested the hypothesis that MV leaflet surface area increases over time with mechanical stretch created by papillary muscle displacement through cell activation, not passive stretching.
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pubmed:affiliation |
Massachusetts General Hospital, Cardiac Ultrasound Laboratory, Harvard Medical School, Boston, MA 02114, USA.
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