Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1992-1-3
|
pubmed:abstractText |
The hypothesis was tested that the magainin peptides, known to compromise bacterial and mitochondrial energetics, are highly active against spermatozoa. A mixture of magainin A and PGLa (1:1) caused a 50% reduction in motility of hamster spermatozoa at 4 micrograms/ml total peptide concentration. All motility was lost at 8 micrograms/ml. At this concentration, respiratory control was released and respiration in the presence of uncoupler was inhibited. Uptake of the lipophilic cation tetraphenyl phosphonium was largely abolished by addition of magainin A and PGLa showed synergism with respect to release of respiratory control.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0014-5793
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
18
|
pubmed:volume |
293
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
219-23
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:1959667-Amino Acid Sequence,
pubmed-meshheading:1959667-Animals,
pubmed-meshheading:1959667-Antimicrobial Cationic Peptides,
pubmed-meshheading:1959667-Cricetinae,
pubmed-meshheading:1959667-Male,
pubmed-meshheading:1959667-Membrane Potentials,
pubmed-meshheading:1959667-Mitochondria,
pubmed-meshheading:1959667-Molecular Sequence Data,
pubmed-meshheading:1959667-Oxidative Phosphorylation,
pubmed-meshheading:1959667-Peptides,
pubmed-meshheading:1959667-Sperm Motility,
pubmed-meshheading:1959667-Spermatids,
pubmed-meshheading:1959667-Spermatocidal Agents,
pubmed-meshheading:1959667-Spermatozoa
|
pubmed:year |
1991
|
pubmed:articleTitle |
Magainins affect respiratory control, membrane potential and motility of hamster spermatozoa.
|
pubmed:affiliation |
Section of Molecular Biology, Netherlands Cancer Insitute, Amsterdam.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|