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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1992-1-7
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pubmed:abstractText |
Tropine (tropan-3 alpha-ol) is an intermediate in the formation of hyoscyamine. An acyltransferase activity that can acetylate tropine using acetylcoenzyme A as cosubstrate has been found in transformed root cultures of Datura stramonium. A further acyltransferase activity that acetylates pseudotropine (tropan-3 beta-ol) with acetyl-coenzyme A is also present. These two activities can be partially resolved by anion-exchange chromatography, some fractions containing only the pseudotropine-utilizing activity. The basic properties of these two enzymes are reported and their roles in forming the observed alkaloid spectrum of D. stramonium roots discussed.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Nov
|
pubmed:issn |
0014-5793
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
4
|
pubmed:volume |
292
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
293-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1959620-Acetyltransferases,
pubmed-meshheading:1959620-Atropine,
pubmed-meshheading:1959620-Chromatography, Ion Exchange,
pubmed-meshheading:1959620-Datura stramonium,
pubmed-meshheading:1959620-Hydrogen-Ion Concentration,
pubmed-meshheading:1959620-Plants, Medicinal,
pubmed-meshheading:1959620-Plants, Toxic,
pubmed-meshheading:1959620-Tropanes
|
pubmed:year |
1991
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pubmed:articleTitle |
The formation of 3 alpha- and 3 beta-acetoxytropanes by Datura stramonium transformed root cultures involves two acetyl-CoA-dependent acyltransferases.
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pubmed:affiliation |
Genetics and Microbiology Department, AFRC Institute of Food Research, Norwich Laboratory, UK.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|